Selected Publications
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Alveolar epithelial progenitor cells require Nkx2-1 to maintain progenitor-specific epigenomic state during lung homeostasis and regeneration
Toth A, Kannan P, Snowball J, Kofron M, Wayman, JA, Bridges JP, Miraldi ER, Swarr D, Zacharias WJ. Nature Communications. 2023 Dec 19; 14(8452). doi:10.1038/s41467-023-44184-0. Epub 2023 Dec 19.
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Inflammatory blockade prevents injury to the developing pulmonary gas exchange surface in preterm primates
Toth A, Steinmeyer S, Kannan P, Gray J, Jackson CM, Mukherjee S, Demmert M, Sheak JR, Benson D, Kitzmiller J, Wayman JA, Presicce P, Cates C, Rubin R, Chetal K, Du Y, Miao Y, Gu M, Guo M, Kalinichenko VV, Kallapur SG, Miraldi ER, Xu Y, Swarr D, Lewkowich I, Salomonis N, Miller L, Sucre JS, Whitsett JA, Chougnet CA, Jobe AH, Deshmukh H, Zacharias WJ. Sci Transl Med. 2022 Mar 30;14(638):eabl8574. doi: 10.1126/scitranslmed.abl8574. Epub 2022 Mar 30. PMID: 35353543; PMCID: PMC9082785.
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Regeneration of the lung alveolus by an evolutionarily conserved epithelial progenitor
Zacharias WJ, Frank DB, Zepp JA, Morley MP, Alkahleel FA, Kong J, Zhou S, Cantu E, Morrisey EE. Nature. 2018 Mar 8;555(7695):251-255. doi: 10.1038/nature25786. Epub 2018 Feb 28. PMID 29489752, PMCID: PMC6020060
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A census of the lung: CellCards from LungMAP
Sun X, Perl AK, Li R, Bell SM, Sajti E, Kalinichenko VV, Kalin TV, Misra RS, Deshmukh H, Clair G, Kyle J, Crotty Alexander LE, Masso-Silva JA, Kitzmiller JA, Wikenheiser-Brokamp KA, Deutsch G, Guo M, Du Y, Morley MP, Valdez MJ, Yu HV, Jin K, Bardes EE, Zepp JA, Neithamer T, Basil MC, Zacharias WJ, Verheyden J, Young R, Bandyopadhyay G, Lin S, Ansong C, Adkins J, Salomonis N, Aronow BJ, Xu Y, Pryhuber G, Whitsett J, Morrisey EE; NHLBI LungMAP Consortium. Dev Cell. 2022 Jan 10;57(1):112-145.e2. doi: 10.1016/j.devcel.2021.11.007. Epub 2021 Dec 21. PMID: 34936882.
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PI3K signaling specifies proximal-distal fate by driving a developmental gene regulatory network in SOX9+ mouse lung progenitors
Khattar D, Fernandes S, Snowball J, Guo M, Gillen MC, Jain SS, Sinner D, Zacharias W, Swarr DT. Elife. 2022 Aug 17;11:e67954. doi: 10.7554/eLife.67954. PMID: 35976093; PMCID: PMC9427112.
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A potent myeloid response is rapidly activated in the lungs of premature Rhesus macaques exposed to intra-uterine inflammation.
Jackson CM, Demmert M, Mukherjee S, Isaacs T, Thompson R, Chastain C, Gray J, Senthamaraikannan P, Presicce P, Chetal K, Salomonis N, Miller LA, Jobe AH, Kallapur SG, Zacharias WJ, Lewkowich IP, Deshmukh H, Chougnet CA. Mucosal Immunol. 2022 Mar 21. doi: 10.1038/s41385-022-00495-x. Epub ahead of print. PMID: 35314757.
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National Heart, Lung, and Blood Institute and Building Respiratory Epithelium and Tissue for Health (BREATH) Consortium Workshop Report: Moving Forward in Lung Regeneration
Hynds RE, Zacharias WJ, Nikolić MZ, Königshoff M, Eickelberg O, Gosens R, de Coppi P, Janes SM, Morrisey E, Clevers H, Ryan AL, Stripp BR, Sun X, Kim CF, Lin QS. Am J Respir Cell Mol Biol. 2021 Jul;65(1):22-29. doi: 10.1165/rcmb.2020-0397WS. PMID: 33625958; PMCID: PMC8320125.
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The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future.
Basil, MC; Katzen, J; Engler, AE; Guo, M; Herriges, MJ; Kathiriya, JJ; Windmueller, R; Ysasi, AB; Zacharias, WJ; Chapman, HA; et al. Cell Stem Cell. 2020; 26:482-502.
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Early lineage commitment defines alveolar epithelial ontogeny in the lung
Frank DB, Jain R, Penkala IA, Zepp JA, Zacharias WJ, Stolz KG, Pankin J, Li, M, Babu A, Li L, Zhou S, Morley MP, Morrisey EE. Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4362-4371. doi: 10.1073/pnas.1813952116.Epub 2019 Feb 19. PMID 30782824, PMCID: PMC6410851
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Distinct mesenchymal lineages and niches promote epithelial self-renewal and myofibrogenesis in the lung
Zepp JA, Zacharias WJ, Frank DB, Cavanaugh CA, Morley MP, Morrisey EE. Cell. 2017 Sep 7;170(6):1134-1148.e10. doi: 10.1016/j.cell.2017.07.034. PMID 28886382, PMCID: PMC5718193
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Hedgehog signaling controls homeostasis of adult intestinal smooth muscle
Zacharias WJ, Madison BB, Kretovich KE, Walton KD, Richards N, Udager AM, Li X, Gumucio DL. Dev Biol. 2011 Jul 1;355(1):152-62. doi: 10.1016/j.ydbio.2011.04.025. Epub 2011 Apr 28. (Cover Article). PMID: 21545794, PMCID: PMC3118277here
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Epithelial Hedgehog is an anti-inflammatory signal to the intestinal lamina propria
Zacharias WJ, Madison BB, Walton KD, Li X, Kretovich K, Gumucio DL. Gastroenterology. 2010 Jun;138(7):2368-77, 2377.e1-4. doi: 10.1053/j.gastro.2010.02.057.Epub 2010 Mar 3. PMID: 20206176. PMCID: PMC2883680.
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Analysis of germline GLI1 variation implicates Hedgehog signaling in the regulation of intestinal inflammatory pathways
Lees C*, Zacharias WJ* et al., PLoS Med. 2008 Dec 9;5(12):e239. doi: 10.1371/journal.pmed.0050239. PMID: 19071955, PMCID: PMC2596854 (* denotes co-first authorship).